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Losartan may prevent the elevation of plasma glucose levels induced by chronic stress
Yağiz Uresin1, Bahar Erbaş, Mehmet Ozek
1Istanbul University, Istanbul Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 34390 Capa, Istanbul, Turkey. yagiz@istanbul.edu.tr
Abstract:
The effect of angiotensin II antagonist, losartan, on chronic stress-induced elevation of blood glucose levels was investigated in rats. Chronic immobilization stress caused an increase in blood glucose levels in rats. Administration of losartan (3 mg/kg, po) before stress exposure significantly prevented this increment. We suggest that losartan showed this effect by decreasing the excessive sympathetic response to stress. In conclusion, there is a relationship between stress, sympathetic nervous system, and renin-angiotensin system.
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