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Chlorpheniramine for motion sickness.

Jay C Buckey1, Donna Alvarenga, Bernard Cole

  • 1Department of Medicine, Dartmouth Medical School, One Medical Center Dr., Lebanon, New Hampshire 03756, USA. jay.buckey@dartmouth.edu

Journal of Vestibular Research : Equilibrium & Orientation
|May 25, 2004
PubMed
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Chlorpheniramine effectively treats motion sickness, increasing tolerance to rotational stimuli. While it can cause drowsiness, it does not impair cognitive function, offering a potential new remedy.

Area of Science:

  • Aerospace Medicine
  • Human Physiology
  • Pharmacology

Background:

  • Motion sickness poses challenges for travelers and professionals in aviation, naval, and space operations.
  • Existing remedies often cause sedation, limiting their utility.
  • Developing non-sedating or less-sedating treatments is crucial.

Purpose of the Study:

  • To evaluate chlorpheniramine as a potential treatment for motion sickness.
  • To determine the optimal dosage of chlorpheniramine for efficacy.
  • To assess the impact of chlorpheniramine on cognitive performance.

Main Methods:

  • A placebo-controlled, double-blind, dose-ranging trial was conducted.
  • Eighteen motion sickness-susceptible subjects received placebo, 4 mg, or 12 mg of chlorpheniramine.
Keywords:
Non-programmatic

Related Experiment Videos

  • Cognitive function was assessed using objective and subjective tests before and after rotation.

    • Main Results:

    • Chlorpheniramine significantly increased tolerance to motion sickness at both low and high doses.
    • High-dose chlorpheniramine led to increased sleepiness and decreased alertness.
    • Cognitive performance on objective tests remained unaffected by chlorpheniramine.

    Conclusions:

    • Chlorpheniramine demonstrates efficacy in combating motion sickness.
    • The drug's potential for transdermal administration warrants further investigation.
    • Chlorpheniramine presents a viable option for motion sickness management, with considerations for its side effects.