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Related Experiment Videos

p300/CBP and cancer.

Narayanan Gopalakrishna Iyer1, Hilal Ozdag, Carlos Caldas

  • 1Cancer Genomics Program, Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge CB2 2XZ, UK.

Oncogene
|May 25, 2004
PubMed
Summary

p300 and cyclic AMP response element-binding protein (CBP) are crucial tumor suppressors. Mutations in these proteins are linked to various cancers, including childhood malignancies and hematological disorders, highlighting their role in cancer development.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • p300 and cyclic AMP response element-binding protein (CBP) are key proteins involved in cellular processes.
  • They function as transcriptional co-factors and histone acetyltransferases.
  • Germline and somatic mutations in CBP and p300 are associated with various cancers.

Purpose of the Study:

  • To investigate the role of p300 and CBP in tumorigenesis.
  • To understand the mechanisms by which mutations in these genes contribute to cancer development.

Main Methods:

  • Analysis of mutations in human cancers (acute myeloid leukemia, solid tumors).
  • Examination of chromosome translocations involving CBP and p300.
  • Utilizing a mouse model to study the function of p300 and CBP in tumor suppression.

Main Results:

  • Mutations in p300 and CBP lead to truncated proteins or altered critical domains.
  • Inactivation of the second allele is often observed with p300 mutations in solid tumors.
  • A mouse model confirmed the tumor suppressor role of p300 and CBP in hematological malignancies.

Conclusions:

  • p300 and CBP are critical tumor suppressors.
  • Their inactivation through mutations or translocations contributes to cancer development.
  • These proteins are involved in key cancer pathways like TGF-beta, p53, and Rb.

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