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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?

C D Scott1, S M Firth

  • 1Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. cscott@med.usyd.edu.au

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 25, 2004
PubMed

Insights

The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-IIR) has dual roles. This review explores if M6P/IGF-IIR directly suppresses tumors or indirectly aids tumor progression by transporting growth factors.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-IIR) is predominantly intracellular, crucial for lysosomal enzyme transport.
  • A cell surface pool of M6P/IGF-IIR interacts with diverse ligands, including growth factors like IGF-II and TGF-beta.

Purpose of the Study:

  • To investigate the dual role of M6P/IGF-IIR in cancer.
  • To determine if M6P/IGF-IIR acts as a direct tumor suppressor or indirectly influences tumor progression.

Main Methods:

  • Literature review focusing on M6P/IGF-IIR localization and function.
  • Analysis of M6P/IGF-IIR interactions with ligands such as IGF-II and TGF-beta in the context of cancer.

Main Results:

  • M6P/IGF-IIR's intracellular function is vital for lysosomal enzyme trafficking.
  • Loss of M6P/IGF-IIR is observed in certain tumors, suggesting a potential tumor suppressive role.
  • The cell surface M6P/IGF-IIR's role in binding growth factors is under investigation regarding tumor growth.

Conclusions:

  • The precise role of M6P/IGF-IIR in cancer remains to be fully elucidated.
  • Further research is needed to differentiate between direct tumor suppression and indirect effects mediated by ligand transport.

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