Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluation of autonomic function.

P A Low1

  • 1Department of Neurology, Mayo Clinic, Rochester.

Current Opinion in Neurology and Neurosurgery
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Evaluating adrenergic function using the Valsalva maneuver shows promise for clinical use. Progressive adrenergic failure impacts specific phases (IIl, IIe, IV) and baroreflex responses, offering insights into sympathetic activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accuracy of chat-based artificial intelligence for patient education on orthostatic hypotension.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2025
Same author

Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis.

Neurogastroenterology and motility·2016
Same author

Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motility disorders.

Neurogastroenterology and motility·2015
Same author

Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2015
Same author

Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome.

Neurogastroenterology and motility·2014
Same author

Midodrine efficacy in orthostatic hypotension.

Journal of general internal medicine·2014
Same journal

Neuropharmacology.

Current opinion in neurology and neurosurgery·1993
Same journal

Disorders of the spinal cord and cauda equina.

Current opinion in neurology and neurosurgery·1993
Same journal

Autonomic disorders.

Current opinion in neurology and neurosurgery·1993
Same journal

Molecular and cell biology of addiction.

Current opinion in neurology and neurosurgery·1993
Same journal

Molecular mechanisms of trauma-induced neuronal degeneration.

Current opinion in neurology and neurosurgery·1993
Same journal

Excitatory amino acid receptors and epilepsy.

Current opinion in neurology and neurosurgery·1993
See all related articles

Area of Science:

  • Autonomic Nervous System Physiology
  • Cardiovascular Regulation

Background:

  • Current clinical laboratory tests for adrenergic function lack sensitivity.
  • The Valsalva maneuver is being explored as a tool to assess adrenergic function.
  • Understanding sympathetic and parasympathetic balance is crucial for diagnosing autonomic disorders.

Purpose of the Study:

  • To evaluate the utility of Valsalva maneuver components in assessing adrenergic function.
  • To investigate the relationship between progressive adrenergic failure and specific Valsalva maneuver phases.
  • To explore alternative methods for evaluating baroreflex sensitivity and autonomic balance.

Main Methods:

  • Analysis of late phase II and phase IV of the Valsalva maneuver.
  • Assessment of heart period/blood pressure (BP) response for baroreflex gain.

Related Experiment Videos

  • Application of power spectral analysis to heart rate recordings for autonomic balance.
  • Utilizing prolonged tilt tests and isoproterenol infusion during tilt.

    • Main Results:

    • Progressive adrenergic failure is characterized by loss of phase III, increased phase IIe, and loss of phase IV.
    • Baroreflex gain can be assessed via heart period/BP response, with latency as a potential alternative.
    • Power spectral analysis offers insights into human parasympathetic/sympathetic balance.
    • Prolonged tilt tests are sensitive for vasodepressor syncope, but isoproterenol infusion lacks specificity.

    Conclusions:

    • Components of the Valsalva maneuver can aid in the clinical evaluation of adrenergic function.
    • Specific changes in Valsalva phases correlate with the degree of adrenergic failure.
    • Further validation is needed for power spectral analysis and latency-based baroreflex assessment in clinical settings.