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Lipid rafts: microenvironments for integrin-growth factor interactions in neural development
L Decker1, W Baron, C Ffrench-Constant
1Department of Pathology, Cambridge Centre for Brain Repair, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Abstract:
The development of a complex multicellular organ such as the nervous system requires precise regulation of cell migration, proliferation and survival. This regulation in turn requires the integration of long-range signals, such as growth factors, with short-range cues that define the precise location and cellular neighbours for any given cell. This short review examines one integrative mechanism, integrin-growth factor receptor interactions, and explores the role of lipid rafts in the molecular mechanisms that underlie the receptor interactions.
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