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Annexin 1 and neutrophil apoptosis

M Perretti1, E Solito

  • 1The William Harvey Research Institute, Queen Mary University of London, Bart's and the London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. M.Perretti@qmul.ac.uk

Biochemical Society Transactions
|May 26, 2004
PubMed

Insights

Annexin 1 (ANXA1), a protein regulating inflammation, also promotes apoptosis. This finding offers new insights into inflammation pathophysiology and leukocyte recruitment.

Area of Science:

  • Biochemistry
  • Immunology
  • Cell Biology

Background:

  • Annexin 1 (ANXA1) is known for mediating anti-inflammatory effects of glucocorticoids.
  • ANXA1 regulates neutrophil adhesion in inflamed blood vessels.
  • ANXA1 is found in inflammatory exudates and produced by neutrophils.

Purpose of the Study:

  • To review the proapoptotic effects of ANXA1.
  • To discuss the role of ANXA1 in inflammation and leukocyte recruitment.

Main Methods:

  • Literature review of ANXA1 functions.
  • Analysis of ANXA1's role in inflammatory processes.

Main Results:

  • ANXA1 exhibits novel proapoptotic properties.
  • ANXA1's functions extend beyond regulating neutrophil adhesion.

Conclusions:

  • ANXA1's proapoptotic effect is significant for understanding inflammation.
  • ANXA1 plays a complex role in the pathophysiology of inflammation and leukocyte recruitment.

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