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Intracerebral Meningiomas.

Marc C. Chamberlain1

  • 1Department of Neurology and Neurosurgery, University of Southern California, 1441 Eastlake Avenue, Suite 3459, Los Angeles, CA 90033, USA. chamberl@usc.edu

Current Treatment Options in Neurology
|May 26, 2004
PubMed
Summary

Meningiomas, common brain tumors, are often treated with surgery. Radiotherapy and immunochemotherapy offer alternatives for recurrent or unresectable cases, improving patient outcomes.

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Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Radiation Oncology

Background:

  • Meningiomas are extra-axial brain tumors with a female predominance, typically affecting middle to late adult life.
  • While 90% are benign, treatment decisions are guided by symptoms, with complete surgical resection often being curative.
  • Incomplete resection or recurrence may necessitate radiotherapy, with stereotactic approaches gaining prominence.

Purpose of the Study:

  • To review the treatment modalities for meningiomas, including surgery, radiotherapy, and immunochemotherapy.
  • To highlight the indications and evolving role of stereotactic radiotherapy.
  • To discuss therapeutic options for unresectable or treatment-resistant meningiomas.

Main Methods:

  • Review of existing literature on meningioma treatment.
  • Analysis of surgical resection, radiotherapy (conventional and stereotactic), and immunochemotherapy.
  • Discussion of treatment strategies based on tumor characteristics and patient factors.

Main Results:

  • Complete surgical resection is the primary curative treatment for most meningiomas.
  • Radiotherapy, particularly stereotactic radiosurgery, is an effective option for specific patient groups and tumor locations.
  • Immunochemotherapy shows modest success in recurrent or aggressive meningiomas, with various agents utilized.

Conclusions:

  • Meningioma management involves a spectrum of treatments tailored to individual cases.
  • Stereotactic radiotherapy presents a valuable alternative to surgery in select patients.
  • Further research into immunochemotherapy may offer improved options for advanced meningiomas.

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