Snapshots of membrane-translocating proteins

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Updated: Aug 24, 2026

Visualizing Intracellular SNARE Trafficking by Fluorescence Lifetime Imaging Microscopy
08:55

Visualizing Intracellular SNARE Trafficking by Fluorescence Lifetime Imaging Microscopy

Published on: December 29, 2017

B Martoglio1, B Dobberstein

  • 1ZMBH (Zentrum für Molekulare Biologie der Universität Heidelberg), Postfach 106249, 69052 Heidelberg, Germany.

Trends in Cell Biology
|April 1, 1996
PubMed

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Protein Translocation Machinery on the ER Membrane

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Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the translocon complex.
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Cotranslational Protein Translocation

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Insertion of Single-pass Transmembrane Proteins in the RER

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Post-translational Translocation of Proteins to the RER

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Insertion of Multi-pass Transmembrane Proteins in the RER

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Translocation of Proteins into the Mitochondria

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Sorting of outer membrane proteins:
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