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The Digital Cytocochleogram.

P A Santi1, A Blair, B A Bohne

  • 1Department of Otolaryngology, University of Minnesota, Rm. 121, Lions Res. Build., 2001 Sixth St. SE, Minneapolis 55455, USA. p.santi@amn.edu

Hearing Research
|May 26, 2004
PubMed
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The Mouse Cochlea Database now features the Digital Cytocochleogram, offering interactive mouse cochlea images for anatomical study. This resource allows users to explore hair cell data and measure structures within the organ of Corti.

Area of Science:

  • Otoacoustic Emissions
  • Auditory Neuroscience
  • Mammalian Genetics

Background:

  • The Mouse Cochlea Database (MCD) compiles digital images and bibliographic data for mouse cochlear research.
  • A cytocochleogram graphically represents the hair cell status across the organ of Corti's length and width.

Purpose of the Study:

  • To introduce the Digital Cytocochleogram, a new resource within the MCD.
  • To provide researchers with a collection of digital images for morphometric analysis of the mouse organ of Corti.

Main Methods:

  • The Digital Cytocochleogram utilizes Coordinate Finder and Viewer software (CGI scripts).
  • Coordinate Finder maps images to an X,Y system; an arc-distance formula calculates organ of Corti length.
  • The Viewer program enables web-based morphometric assessment of anatomical structures.

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Main Results:

  • A complete surface preparation from a normal mouse is currently available.
  • The system displays anatomical structure location and approximate frequency region via cursor interaction.
  • Users can measure distances between structures on the digital images.

Conclusions:

  • The Digital Cytocochleogram enhances the Mouse Cochlea Database with interactive morphometric tools.
  • Future updates will include diverse magnifications and preparations from normal, mutant, and altered mouse cochleas.
  • This resource facilitates detailed anatomical research on the mouse cochlea.