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Updated: Aug 24, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans
Published on: June 25, 2013
[Isoprostanes: a putative key role in vascular diseases]
1Laboratoire de pharmacologie, HP2, faculté de médecine de Grenoble, domaine de la Merci, 38700 La Tronche, France. jean-luc.cracowski@ujf-grenoble.fr
Purpose:
Isoprostanes are arachidonic acid metabolites produced by a free-radical-dependent mechanism.
Current Knowledge And Key Points:
The 15-series F2-isoprostanes and some 15-series E2-isoprostanes mediate vasoconstriction in different vascular beds and species. Furthermore, 15-F2t-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. In clinical studies, 15-F2t-IsoP levels are increased in vascular disorders involving atherosclerosis, ischemia-reperfusion and inflammation.
Future Prospects And Projects:
Whether the effects observed in vitro are observed consistently in vivo at physiological concentrations and whether these effects contribute to pathological states in vivo is still debated.
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