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Pregnancy and autoimmune diseases
1Department of Rheumatology, Division of Immunity, Infection, The Medical School, University of Birmingham, Birmingham, UK. p.c.gordon@bham.ac.uk
Best Practice & Research. Clinical Rheumatology
|May 26, 2004
Summary
Women with autoimmune rheumatic diseases can safely have children by managing disease activity and medication. This reduces risks of maternal and fetal complications during pregnancy.
Area of Science:
- Rheumatology
- Obstetrics
- Immunology
Background:
- Historically, pregnancy was contraindicated for women with autoimmune rheumatic diseases due to high maternal and fetal risks.
- Recent advancements suggest risks can be mitigated through careful management.
Purpose of the Study:
- To review evidence on managing pregnancy in women with autoimmune rheumatic diseases.
- To discuss pre-conception counseling regarding disease influence, fertility, and pregnancy outcomes.
Main Methods:
- Review of evidence from retrospective and prospective studies.
- Discussion of clinical considerations for pregnancy in autoimmune rheumatic diseases.
Main Results:
- Pregnancy risks in autoimmune rheumatic diseases are reduced by controlling disease activity and medication.
- Anti-phospholipid antibody syndrome is a significant cause of adverse pregnancy outcomes.
Conclusions:
- Pregnancy is feasible for women with autoimmune rheumatic diseases with proper management.
- Pre-conception counseling is crucial for optimizing maternal and fetal health.