Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Food effects on tablet disintegration.

Bertil Abrahamsson1, Tamsin Albery, Anna Eriksson

  • 1AstraZeneca, Pharmaceutical and Analytical R&D, S-43183 Mölndal, Sweden. bertil.abrahamsson@astrazeneca.com

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|May 26, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supporting people with an acquired brain injury (ABI) involved in the criminal justice system: justice and allied health professionals' insights.

Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law·2026
Same author

Development and initial psychometric evaluation of a questionnaire for post intensive care recovery - PIR.

Journal of patient-reported outcomes·2026
Same author

Biowaiver monograph for immediate-release solid oral dosage forms: Amlodipine besylate.

Journal of pharmaceutical sciences·2025
Same author

Unexpected effects of antibiotics on microbiota-mediated drug metabolism in a fistulated dog model.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Biowaiver monograph for immediate-release solid oral dosage forms: Empagliflozin.

Journal of pharmaceutical sciences·2025
Same author

Leveraging Biopharmaceutics Bridging Risk Assessment and In Vivo Predictive Tools to Accelerate Immediate Release Drug Product Development by Minimized Need for Clinical Bridging Studies.

Molecular pharmaceutics·2025

Food components, like nutritional drinks, significantly delay tablet disintegration and drug dissolution in the stomach. This occurs due to a protein-rich film forming on tablets, impacting drug delivery.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Gastrointestinal Physiology

Background:

  • Tablet disintegration is crucial for drug release and absorption.
  • Food intake can influence gastric conditions and potentially affect oral dosage forms.

Purpose of the Study:

  • To investigate the effect of food components (nutritional drink) on tablet disintegration in vitro and in vivo.
  • To elucidate the mechanism behind food-induced delays in tablet disintegration.
  • To assess the impact on drug dissolution.

Main Methods:

  • In vitro disintegration tests using simulated gastric fed medium vs. buffer.
  • In vivo studies in dogs with gastric fistulas.
  • Nutrient-specific disintegration studies and precipitate analysis (IR spectroscopy).

Related Experiment Videos

  • Drug dissolution testing (metoprolol tartrate).

    • Main Results:

    • Nutritional drink significantly delayed tablet disintegration (5 min to >1h) compared to buffer.
    • This effect was tablet-composition dependent.
    • In vivo studies confirmed delayed disintegration in canine models.
    • A protein-rich film precipitated on tablets, causing the delay.
    • Drug dissolution of metoprolol tartrate was also significantly delayed.

    Conclusions:

    • Food components can significantly delay tablet disintegration and drug dissolution in the stomach via film formation.
    • In vitro disintegration tests with nutritional drink media can predict this effect.
    • Further research is needed on bioavailability implications and other food types.