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Compression behaviour and tablet-forming ability of spray-dried amorphous composite particles
Jonas Berggren1, Göran Frenning, Göran Alderborn
1Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden.
Summary
Spray-dried amorphous lactose particles were studied for tablet formation. Adding polymers improved compression, while surfactants hindered tabletability, showing formulation can control powder properties.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Amorphous solid dispersions are crucial for improving drug solubility and bioavailability.
- Spray-drying is a common technique for producing amorphous particles for pharmaceutical applications.
Purpose of the Study:
- To investigate the impact of polyvinylpyrrolidone (PVP) and polysorbate 80 on the compression behavior and tablet-forming ability of spray-dried amorphous lactose.
- To characterize the physical properties of composite particles relevant to powder compression.
Main Methods:
- Spray-drying was used to prepare lactose, lactose-PVP, and lactose-PVP-polysorbate 80 composite particles.
- Particle characterization included surface area, moisture content, density, and thermal analysis (glass transition, crystallization).
- Tabletability was assessed by measuring tablet tensile strength at various pressures, with compression parameters derived from Heckel and Kawakita equations.
Main Results:
- Particles containing PVP exhibited reduced permanent deformation during compression.
- The addition of polysorbate 80 decreased the tablet-forming ability of the composite particles.
- Compression parameters indicated that PVP enhanced plastic deformation, while surfactants reduced it.
Conclusions:
- The compression behavior and tablet-forming ability of spray-dried amorphous lactose can be effectively modulated by incorporating stabilizing polymers like PVP.
- Surfactants, such as polysorbate 80, can negatively impact the tabletability of amorphous lactose particles.
- Formulation strategies involving polymers and surfactants offer a means to control the solid-state properties of spray-dried amorphous materials for improved tablet manufacturing.