Related Experiment Video
Updated: Aug 24, 2026

Preparation of Cell Extracts by Cryogrinding in an Automated Freezer Mill
Published on: January 29, 2021
Influence of cryogenic grinding on properties of a self-emulsifying formulation
O Chambin1, V Jannin, D Champion
1Groupe Technologie des Poudres à Usage Pharmaceutique, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne d'Arc, 21 079 Dijon Cedex, France.
Abstract:
Recently, self-emulsifying drug delivery systems (SEDDS) have been developed as a method to deliver lipophilic drugs. Gelucire 44/14 is an excipient, from the lauroyl macrogolglycerides family, producing a fine oil-in-water emulsion when introduced into an aqueous phase under gentle agitation as SEDDS, improving thereby solubility of poorly water-soluble drugs and their bioavailability. The aims of this study were to process Gelucire 44/14 into a powder by cryogenic grinding to produce solid oral dosage forms and to investigate influence of this process on different properties of a formulation made of Gelucire 44/14 and ketoprofen (90/10). Cryogenic grinding produced Gelucire 44/14 in a powder form and this process did not change its physical properties, emulsification capacities and dissolution performances of the formulation tested. However, interactions took place between ketoprofen and Gelucire 44/14 with a decrease of the melting peak and a reduction of the droplet size of the formed emulsion. The influence of drug-Gelucire 44/14 interactions must be investigated case by case in any formulations.
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Cryo-electron Microscopy
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Freezing Point Depression and Boiling Point Elevation
