From atoms to systems: a cross-disciplinary approach to complement-mediated functions

Area of Science:

• Immunology
• Genomics
• Systems Biology

Background:

• Genomic and proteomic data are revolutionizing biological research.
• A shift towards studying interactive biological systems and dynamic networks is occurring.
• The complement system serves as a model for applying cross-disciplinary approaches in immunology.

Purpose of the Study:

• To elucidate key aspects of complement functions.
• To determine the role of complement proteins in inflammatory and developmental processes.
• To present recent findings on complement inhibitors, protein interactions, viral immune evasion, and complement evolution.

Main Methods:

• Cross-disciplinary research approach.
• Analysis of genomic and protein structure databases.
• Investigating protein-protein interactions.
• Studying viral immune evasion mechanisms.

Main Results:

• Recent findings on the rational development of complement inhibitors.
• Studies detailing protein-protein interactions within the complement system.
• Progress in understanding viral strategies for evading complement-mediated immunity.
• Identification of complement components involved in organ regeneration, hematopoietic development, and stem cell engraftment.

Conclusions:

• The complement system is a dynamic network with roles beyond traditional immunology.
• Cross-disciplinary approaches are crucial for understanding complex biological systems.
• Complement research has implications for developing novel therapeutics and understanding developmental processes.