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Related Experiment Videos

Ingested fat and satiety.

Patrick Tso1, Min Liu

  • 1Department of Pathology, University of Cincinnati Medical Center, 231 Albert Sabin Way (ML 0529), Cincinnati, OH 45267-0529, USA. tsopp@email.uc.edu

Physiology & Behavior
|May 26, 2004
PubMed
Summary
This summary is machine-generated.

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Apolipoprotein A-IV (apo A-IV) regulates food intake by acting in the brain and intestine. Fat intake stimulates apo A-IV, which may explain how high-fat diets contribute to obesity.

Area of Science:

  • Metabolism
  • Neuroscience
  • Endocrinology

Background:

  • Apolipoprotein A-IV (apo A-IV) is synthesized in the intestine and associated with chylomicrons.
  • Intestinal apo A-IV synthesis increases with fat absorption and may be influenced by leptin and peptide tyrosine-tyrosine (PYY).

Purpose of the Study:

  • To investigate the role of apo A-IV in regulating food intake and body weight.
  • To explore the central and peripheral mechanisms of apo A-IV action on appetite.

Main Methods:

  • Studied apo A-IV levels in the hypothalamus and intestine under different feeding conditions.
  • Administered apo A-IV antiserum and neuropeptide Y (NPY) centrally to assess effects on feeding behavior and gene expression.
  • Examined the impact of chronic high-fat diet on intestinal apo A-IV response.

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Main Results:

  • Hypothalamic apo A-IV levels decrease with food deprivation and increase with lipid feeding.
  • Central administration of apo A-IV antiserum stimulates feeding, while NPY increases hypothalamic apo A-IV mRNA.
  • Chronic high-fat intake blunts the intestinal apo A-IV response to lipids.

Conclusions:

  • Apo A-IV plays a significant role in both short-term and long-term regulation of food intake and body weight.
  • The findings suggest that impaired apo A-IV response to dietary fat may contribute to obesity.
  • Apo A-IV's central action in the hypothalamus is crucial for limiting food intake.