Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioids and alcoholism.

L M Oswald1, G S Wand

  • 1Departments of Medicine and Psychiatry, The Johns Hopkins University, School of Medicine, Ross Research Building, Room 863, 720 Rutland Avenue, Baltimore, MD 21205, USA.

Physiology & Behavior
|May 26, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No allelic association of an exon 13 polymorphism of the Gsα gene to alcohol and/or drug dependence.

Addiction biology·2016
Same author

Recurrence of hyperprolactinemia after withdrawal of long-term cabergoline therapy.

The Journal of clinical endocrinology and metabolism·2009
Same author

GABRA6 gene polymorphism and an attenuated stress response.

Molecular psychiatry·2004
Same author

Naltrexone dampens ethanol-induced cardiovascular and hypothalamic- pituitary-adrenal axis activation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2001
Same author

Association of IGF-I levels with muscle strength and mobility in older women.

The Journal of clinical endocrinology and metabolism·2001
Same author

Serum 6-beta-naltrexol levels are related to alcohol responses in heavy drinkers.

Alcoholism, clinical and experimental research·2000
Same journal

Importance of Apparatus Scaling in Novel Object Recognition for Juvenile and Adult Rats.

Physiology & behavior·2026
Same journal

Chronic activity-based anorexia alters food intake microstructure in a time-dependent manner in female rats.

Physiology & behavior·2026
Same journal

Apelin receptor antagonist (ML221) facilitates memory reconsolidation in novel object recognition task.

Physiology & behavior·2026
Same journal

Are humans adapted to the world they have developed?

Physiology & behavior·2026
Same journal

50-kHz ultrasonic vocalization subtypes emitted by female rats anticipating same-sex social interaction.

Physiology & behavior·2026
Same journal

Sex-dependent behavioral and prefrontal BDNF mRNA responses to extinction training and short-term citalopram after fear conditioning in rats.

Physiology & behavior·2026
See all related articles

The endogenous opioid system influences alcoholism. Opioid antagonists show potential in reducing alcohol consumption, especially in those who relapse, though more research is needed.

Area of Science:

  • Neuroscience
  • Addiction Research
  • Pharmacology

Background:

  • Growing evidence links the endogenous opioid system to alcoholism development and maintenance.
  • Ethanol consumption increases opioid neurotransmission, contributing to its reinforcing effects.
  • Individual differences in opioid activity correlate with inherited alcoholism risk.

Purpose of the Study:

  • To summarize current understanding of the endogenous opioid system's role in alcoholism.
  • To highlight progress and remaining questions in opioid system research for alcoholism.
  • To explore the potential of opioid antagonists in alcoholism treatment.

Main Methods:

  • Review of preclinical research on ethanol consumption and opioid neurotransmission.
  • Analysis of human studies examining opioid activity and family history of alcoholism.

Related Experiment Videos

  • Evaluation of clinical trial findings on opioid antagonist efficacy in alcoholics.

    • Main Results:

    • Ethanol consumption and dopamine release are reduced by opioid antagonists in preclinical models.
    • Human studies show parallels with preclinical findings, linking family history to opioid activity.
    • Opioid antagonists may decrease alcohol consumption in clinical trials, particularly in relapsed individuals.

    Conclusions:

    • The endogenous opioid system plays a significant role in ethanol reinforcement and alcoholism.
    • Opioid antagonists show promise for alcoholism treatment, warranting further investigation.
    • Continued research is crucial to fully elucidate the opioid system's complex interaction with alcohol reward and behavior.