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Updated: Aug 24, 2026

Functional Characterization of Endogenously Expressed Human RYR1 Variants
Published on: June 9, 2021
Anti-ryanodine receptor antibodies and FK506 in myasthenia gravis
M Takamori1, M Motomura, N Kawaguchi
1Neurological Center, Kanazawa-Nishi Hospital, Kanazawa, Japan. t-kiyomi@guitar.ocn.ne.jp
Abstract:
Anti-ryanodine receptor (RyR) antibodies were measured in sera from 33 myasthenia gravis (MG) patients using three peptides from the human RyR1 sequence, two C-terminal peptides included in the functional calcium release channel, and an N-terminal peptide implicated in ion-conduction. Antibodies were more frequently positive against the two C-terminal peptides, particularly in thymoma-associated MG. In a preliminary open trial with FK506, immunosuppressant and enhancer of RyR-related sarcoplasmic calcium release, the authors observed the sustained benefits in anti-RyR-positive MG patients.
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