[The study of cellular dynamic varied features on golden hamster cheek pouch premalignant model]

Researching the model of golden hamster cheek pouch premalignancy not only had significance on treating and preventing oral epithelial cancers,but also could furnish the reference material about other similar hidden tumors.In this study,immunohistochemistry ways(proliferation cell nuclear antigen-PCNA,bromodeoxyurdine-BRDU) combined with light and electric microscopic observation were applied to study cellular dynamic varied features on golden hamster cheek pouch premalignant model induced by dimethylbenzanthracence (DMBA).The results showed that both S-period cells and DAN's synthesis increased in the development of premalignancy,then,discovered the basis of cellular dynamics of the model.