[The light microscopic observing analysis of 12-item pathological features on golden hamster cheek pouch dysplasia]

Grading objectively serious degree of oral mucosal premalignancy has instructive significance to its outlook and effectiveness.In order to supply experimental foundation of diagnosis epithelial dysplasis accruately,the sample of golden hamster premalignancy induced by dimethyblenzanthracence(DMBA) were made and observed microscopically.The results were recorded one by one according to 12-item criteria of WHO.The results showed that 12-item criteria could summarized wholly the histopathological varied features in the every stage of epithelial dysplasia The frequency of occurrence of 12-itemcriterias suggests that the starting site of premalignancy be at the basal layer.Abnormal karyokinetic and mitogenic figures have special significance in the epithelial dysplasia of grading diagnosis and judging outlook.