[A study on change of proliferating cell nuclear (PCNA) during DMBA induce golden hamster cheek pouch carcinoma]

109 cases were studied by immunohistochemisty with anti-PCNA antibody specimens which dyed by PCNA immunohistochemistry were counted with net and morphology observed.The results indicated that:a few of PCNA-positive cells had been seen in the basal cells of normal epithelium. An increased percentage of PCNA-positive cells was found in dysplasia and carcinoma.The increase between every grade is of statistical significance(P<0.05).In slight dysplasia grade group,the percentage od PCNA-positive cells increasing between applying DMBA-six-weeks' group is of statistical significance(P<0.05),and hadn't found statistical difference among the other groups.It is demonstrated that PCMA is one of criteria which were observed cell reproduction reactivities during precarcinoma,and it is more sensitive than light microscopy.