[The formation of experimental periodontitis of Guinea pig]

This investigation was used silk suture and high sugar to study the formation of experimental periodontitis.The results showed that the gingival index(GI) and periodontal deep(PD) of all experimental Guinea pig were increased in the first week.There were more lymphocytes and plasmacytes in gingival proper layer in the second week.The plasmacytes and macrophages in gingival proper layer were increased much more in 4th week and alveolar bone was absorbed less,and there were more osteoclasts lying in resorpted area of alveolar bone.In the 8th week,the alveolar bone were resorpted more severe.There were more osteoblasts in the resorpted alveolar bone area besides the osteoclaste.The lysosome and endoplasmic veticulum in lymphocytes were increased.The osteoclasts near resorpted alveolar bone had several nucleus,and there were more lysosome chondriosome and endoplasmic veticulum,and the osteoclasts activity were increased,which suggests that silk suture and high sugar can form experimental periodontitis to Guinea pig and the formation time of experimental periodontitis was in the 4th week later.