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Published on: March 30, 2018
T-cell lymphoblastic lymphoma presenting with a breast mass
Perran Fulden Yumuk1, Adnan Aydiner, Erkan Topuz
1Istanbul University, Istanbul Oncology Institute, Capa, Turkey. fuldenyumuk@superonline.com
Leukemia & Lymphoma
|May 27, 2004
Summary
Secondary breast involvement by lymphoblastic lymphoma (LBL) is rare. This case highlights a young female with precursor T-cell LBL presenting with a breast mass as part of widespread disease.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Lymphomas are the most common tumors metastatic to the breast.
- Secondary breast involvement by lymphoma is uncommon.
Observation:
- A 20-year-old female presented with weight loss, night sweats, fatigue, and a left breast mass.
- Physical examination revealed a left breast mass, lymphadenopathy, bilateral pleural effusion, and hepatomegaly.
- Ultrasound identified a 1.7 cm left breast mass; biopsy confirmed diffuse infiltration by atypical cells positive for CD3.
Findings:
- The patient was diagnosed with the leukemic phase of precursor T-cell lymphoblastic lymphoma (LBL).
- Treatment with CHOP chemotherapy, intrathecal methotrexate, and cranial radiotherapy resulted in a complete response.
- The patient later developed central nervous system (CNS) involvement and experienced a rapid disease progression.
Implications:
- Breast involvement is an infrequent manifestation of precursor T-cell LBL/ALL.
- This case underscores the aggressive nature of the disease when it presents with secondary breast involvement.
- Early recognition and comprehensive staging are crucial for managing disseminated lymphoblastic lymphoma.
