Related Experiment Video
Updated: Aug 24, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Preliminary study of the optimal dosing schedule for oral UFT/leucovorin chemotherapy
Sotaro Sadahiro1, Toshiyuki Suzuki, Kenji Ishikawa
1Department of Surgery, Tokai University, Japan. sadahiro@is.icc.u-tokai.ac.jp
Background:
We evaluated the optimal dosage schedule for combined oral chemotherapy using uracil/tegafur (UFT) and leucovorin (LV) in Yoshida sarcoma-bearing rats.
Materials And Methods:
The antitumor activity and survival effect were compared between two schedules, thrice daily administration on 5 days of the week followed by 2 drug-free days (schedule A) and twice daily on 7 days of the week (schedule B).
Results:
Significant tumor growth inhibition and improved survival rate were seen with both schedules of the UFT/LV group as compared to their respective control groups. Tumor growth inhibition was significantly greater in schedule A than schedule B. The number of survivors on day 60 after the tumor inoculation was higher in schedule A although the survival rate did not differ significantly.
Conclusion:
Administration of UFT/LV for 5 days of the week seemed to exhibit superior antitumor activity, with no increase in the incidence of adverse effects, as compared with the consecutive daily dosing schedule.
Related Concept Videos
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Dosage Regimens: Partial Pharmacokinetic Parameters
Dosage Regimen: Multiple Oral Dosage
IV Infusion to Oral Dosing: Conversion Methods
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Bioavailability Study Design: Single Versus Multiple Dose Studies