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Published on: October 30, 2015
Electron conduction across electrode-immobilized neutravidin bound with biotin-labeled ruthenium pentaamine
Sulay D Jhaveri1, Scott A Trammell, Daniel A Lowy
1Nova Research, Inc, 1900 Elkin St, Alexandria, Virginia 22308, USA.
Abstract:
Voltammetry is reported here of a self-assembled redox-protein conjugate consisting of neutravidin conjugated with a biotin derivative redox probe, Ru(NH3)5(N-[(N-[(4-pyridyl)methyl]biotinamide], immobilized on gold electrodes modified by self-assembled monolayers of mercaptoundecanoic acid. This voltammetry indicates that self-assembly of the conjugate/electrode electronic interface, driven by electrostatic binding between the monolayer and a single redox probe, favors orientation of the conjugate, resulting in electronic accessibility of the remaining three redox probes.
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