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Genetic and environmental risk factors for primary open-angle glaucoma
Bao-jian Fan1, Yuk-fai Leung, Ning Wang
1Department of Ophthalmology & Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Chinese Medical Journal
|May 27, 2004
Summary
Primary open-angle glaucoma (POAG) risk factors include family history, hypertension, and smoking. Interestingly, alcohol consumption appears protective against POAG in this Chinese population study.
Area of Science:
- Ophthalmology
- Genetics
- Public Health
Background:
- Primary open-angle glaucoma (POAG) involves optic nerve damage and is genetically diverse.
- Understanding POAG's genetic and environmental influences is crucial for effective management.
Purpose of the Study:
- To investigate the associations between genetic and environmental factors and POAG.
- To identify specific risk and protective factors for POAG in a Chinese population.
Main Methods:
- A hospital-based study included 32 adult POAG patients and 96 controls.
- Multivariable logistic regression analyzed relationships between POAG and factors like family history, hypertension, smoking, alcohol, and gene polymorphisms (myocilin, optineurin).
Main Results:
- POAG was linked to family history, cardiovascular disease, alcohol consumption, and a myocilin T353I alteration (univariate analysis).
- Multivariable analysis confirmed significant associations with family history (OR=20.2), hypertension (OR=3.58), smoking (OR=10.8), alcohol (OR=0.028), and T353I (OR=6.03).
Conclusions:
- Family history, hypertension, cigarette smoking, and the myocilin T353I variant are identified risk factors for POAG.
- Alcohol consumption demonstrated a protective effect against POAG in this study population.