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Muscle strength in type 2 diabetes.

Henning Andersen1, Søren Nielsen, Carl E Mogensen

  • 1Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark. hande@akh.aaa.dk

Diabetes
|May 27, 2004
PubMed
Summary

Type 2 diabetes patients often experience muscle weakness in their ankles and knees. This weakness is linked to the severity of peripheral neuropathy, impacting motor function.

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Area of Science:

  • Neurology
  • Endocrinology
  • Sports Medicine

Background:

  • Motor function deficits are a poorly understood complication of type 2 diabetes.
  • Peripheral neuropathy is common in type 2 diabetes, but its impact on muscle strength is unclear.

Purpose of the Study:

  • To investigate the relationship between peripheral neuropathy and muscle strength in type 2 diabetes patients.
  • To assess muscle strength at multiple joints (elbow, wrist, knee, ankle) and correlate it with neuropathy severity.

Main Methods:

  • Isokinetic dynamometry was used to measure muscle strength in 36 type 2 diabetes patients and 36 matched controls.
  • Neuropathy severity was quantified using clinical scores, nerve conduction studies, and sensory testing, resulting in a neuropathy rank-sum score (NRSS).
  • Nephropathy and retinopathy were also evaluated.

Main Results:

  • Type 2 diabetes patients showed significant strength reductions in ankle flexors (17%) and extensors (14%), and knee flexors (14%).
  • Muscle strength at the elbow and wrist was preserved.
  • The NRSS was inversely correlated with ankle and knee strength, indicating that greater neuropathy severity was associated with weaker muscles.

Conclusions:

  • Peripheral neuropathy, not nephropathy or retinopathy, is significantly associated with reduced muscle strength at the ankle and knee in type 2 diabetes.
  • The findings suggest that peripheral neuropathy contributes to motor dysfunction in type 2 diabetes, particularly affecting lower limb strength.

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