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Updated: Sep 3, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Circulating antigen-antibody complexes in patients with immune complex disorders and following kidney transplantation
Abstract:
The presence of circulating soluble complexes antigen-antibody was investigated by means of our simple test (1) in small serum samples of patients before and after kidney transplantation. We found a higher incidence of positive test results in patients with an original diagnosis of chronic glomeruleonephritis following transplantation in 37.1%, than before transplantation (in 28.5%). In both instances, however circulating immune complexes were less frequent than in a previously studied group of patients with chronic glomerulonephritis (66.6%), or particularly in glomerulonephritis cases with the characteristics of disease activity (100%) positivity. In patients suffering from pyelonephritis, a diseases not due to immune complexes, 18% of sera were positive. After transplantation the number of positive sera rose to 35.5% in 13 patients. The reasons for this finding are being analysed.
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