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Calcium-channel blocking agents as therapy for amphotericin B nephrotoxicity
B H Brouhard1, B Baetz-Greenwalt
1Department of Pediatrics, Cleveland Clinic Foundation, OH 44195.
Cleveland Clinic Journal of Medicine
|May 1, 1992
Abstract:
Amphotericin B is a broad-spectrum antifungal agent shown to be effective in the treatment of systemic fungal infections. Unfortunately, therapeutic doses are often associated with a variety of adverse effects, including nephrotoxicity. Studies of the deleterious effects of amphotericin B on the renal microvasculature are yielding clues to sparing kidney function. In selected patients, concomitant use of a calcium-channel blocker may prevent the nephrotoxic effects of amphotericin B and allow full therapeutic doses to be used.