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Related Experiment Videos

Erythema elevatum diutinum: a clinicopathological study.

S M Wilkinson1, J S English, N P Smith

  • 1Department of Dermatology, North Staffordshire Hospital Centre, Stoke-on-Trent, U.K.

Clinical and Experimental Dermatology
|March 1, 1992
PubMed
Summary

Erythema elevatum diutinum, a vasculitis syndrome, often presents with skin lesions. Hypergammaglobulinemia is a common association, and dapsone is the preferred treatment.

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Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Erythema elevatum diutinum (UED) is a rare vasculitis characterized by inflammatory skin lesions.
  • Histopathology reveals a mixed inflammatory infiltrate in affected tissues.

Purpose of the Study:

  • To describe the clinical features and associations of Erythema elevatum diutinum.
  • To evaluate treatment outcomes in a series of patients.

Main Methods:

  • Retrospective case series of 13 patients diagnosed with Erythema elevatum diutinum.
  • Review of clinical data, biopsy findings, and laboratory results.
  • Assessment of treatment responses, particularly to dapsone.

Main Results:

  • The most frequent association observed was hypergammaglobulinemia (monoclonal and polyclonal).

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  • Chronic infections were less common, though some patients showed reactivity to streptococcal antigens.
  • Dapsone was identified as the primary effective treatment.

    • Conclusions:

    • Hypergammaglobulinemia is a significant clinical association with Erythema elevatum diutinum.
    • Dapsone is the recommended initial therapy for this condition.