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Published on: February 19, 2019
[Preliminary observation of CXCR3 expression on peripheral blood lymphocytes from patients with chronic hepatitis B
Li-Yun Shi1, Li-Huang Zhang, Ming-Wei Li
1Institute of Immunology, The First Affiliated Hospital, Zhejiang University, Hangzhou 310016, China.
Aim:
To explore the role of chemokine receptor CXCR3 in pathogenesis of chronic hepatitis B.
Methods:
The expression of CXCR3 on peripheral blood lymphocytes from chronic hepatitis B patients with various degrees of inflammation was detected, and the distributions of CXCR3 on CD4(+) and CD8(+) T lymphocytes were also evaluated by FACS.
Results:
As compared with healthy control, the percentages of CXCR3(+) lymphocytes, monocytes and CD8(+) T cells were increased significantly in chronic hepatitis B patients.
Conclusion:
Above data suggest that chemokine receptor CXCR3 may play an important role in the recruitment of lymphocytes, especially CTLs recruited to inflammation sites.
