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Updated: Aug 24, 2026

Isolation of Human Umbilical Vein Endothelial Cells and Their Use in the Study of Neutrophil Transmigration Under Flow Conditions
Published on: August 8, 2012
[Morphological evidence on participating in adhesive function of human umbilical vein endothelial cells by CD226]
Li-Hua Chen1, Xin-Hai Zhang, Yi-Chao She
1Department of Immunology, Fourth Military Medical University, Xi'an 710032, China.
Aim:
To provide the morphological evidence on participating in the adhesive function of human umbilical vein endothelial cells by CD226.
Methods:
Human umbilical vein endothelial cells(HUVECs) were cultured and the effect of CD226 on the adhesion between activated HUVEC and activated PBMC were observed by Leica inverted microscope and scanning electron microscope.
Results:
Fusion protein CD226/Ig could block the adhesion between activated HUVECs and activated PBMC markedly.
Conclusion:
CD226 was a novel inducible adhesion molecule expressed on activated endothelial cells, which may possess important physiological and pathological function.
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