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Related Experiment Video

Updated: May 5, 2026

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

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Published on: May 13, 2014

Reprogramming committed B lineage cells.

Cornelis Murre¹

¹Divison of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

|May 28, 2004

Summary

This summary is machine-generated.

Mature B lineage cells can be reprogrammed into macrophages, challenging the long-held belief that cell fate is irreversible after commitment. This study reveals a surprising plasticity in specialized immune cells.

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Last Updated: May 5, 2026

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Published on: May 13, 2014

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

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Published on: November 4, 2019

Area of Science:

Immunology
Cell Biology
Developmental Biology

Background:

Cell lineage commitment is typically considered a terminal process, restricting cells to their designated fate.
The stability of differentiated cell states has been a fundamental concept in developmental biology and immunology.

Discussion:

This research challenges the dogma of irreversible cell fate determination in mature immune cells.
The findings suggest that cellular identity, even in committed cells, may be more plastic than previously understood.

Key Insights:

Committed, mature B lineage cells were successfully reprogrammed into functional macrophages.
This reprogramming demonstrates a novel mechanism for cell fate conversion within the hematopoietic system.

Outlook:

Further investigation into the molecular mechanisms driving this B cell to macrophage reprogramming is warranted.
Understanding this plasticity could open new avenues for regenerative medicine and therapeutic strategies targeting immune cell populations.