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Inflammation in patients on peritoneal dialysis is associated with increased extracellular fluid volume

Marlen Vicenté-Martínez1, Leonel Martínez-Ramírez, Rodrigo Muñoz

  • 1Departamento de Medicina Interna, Hospital General 47 Vicente Guerrero, Mexico City, DF, Mexico.

Archives of Medical Research
|May 28, 2004
PubMed

Insights

Patients on peritoneal dialysis often experience fluid overload and inflammation. This study found hyperhydration is linked to inflammation and higher peritoneal transport types in these patients.

Area of Science:

  • Nephrology
  • Cardiovascular Health
  • Internal Medicine

Background:

  • Cardiovascular disorders are a leading cause of mortality in dialysis patients.
  • Factors like fluid overload, hypertension, and inflammation are linked to cardiovascular issues in dialysis.
  • Inflammation is a significant risk factor for mortality in patients undergoing dialysis.

Purpose of the Study:

  • To investigate the relationship between increased extracellular fluid volume, inflammation, and peritoneal transport type (PTT).
  • To assess these factors in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD).

Main Methods:

  • A cross-sectional study compared 20 healthy controls with 21 CAPD and 9 APD patients.
  • Measurements included blood volume (BV), total body water (TBW), inferior vena cava diameter (IVCD), serum albumin, and C-reactive protein (CRP).
  • Peritoneal equilibrium tests (PET) were conducted.

Main Results:

  • Peritoneal dialysis (PD) patients exhibited increased TBW, BV, and IVCD compared to controls.
  • Hypertension was the most common sign of fluid overload in PD patients.
  • PD patients showed hypoalbuminemia and elevated CRP levels, with correlations between CRP and IVCD, and albumin and D/P Cr.

Conclusions:

  • Patients on PD demonstrate increased extracellular fluid volume compared to healthy individuals.
  • Hyperhydration in PD patients is associated with inflammation.
  • Higher peritoneal transport types are linked to increased fluid volume and inflammation in PD patients.
Abstract

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