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Interference with ovulation and luteal function by human ovarian follicular fluid peptide in bonnet monkeys, Macaca
T D Nandedkar1, J K Shahid, S D Kholkute
1Institute for Research in Reproduction, Parel, Bombay, India.
Contraception
|April 1, 1992
Abstract:
Partially purified human ovarian follicular fluid peptide (hGF2) was administered during follicular phase in 5 bonnet monkeys. In control as well as hGF2-injected animals, ovulation was synchronized by treatment with FSH, Pergonal and hCG. All the 5 control bonnet monkeys showed plasma estradiol peak followed by increased progesterone levels. In 4 out of 5 hGF2-injected animals, plasma progesterone levels were drastically reduced. Plasma estradiol levels were decreased only in 3 animals in which amenorrhea was observed. These data reveal that hGF2 injection disrupted ovarian function in bonnet monkeys.