Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Congenital factor VII deficiency.

Jagruti P Sanghvi1, Mamta N Muranjan, S B Bavdekar

  • 1Department of Pediatrics, Seth G S Medical College and K.E.M Hospital, Parel, Mumbai, India.

Indian Journal of Pediatrics
|May 28, 2004
PubMed
Summary

A rare factor VII deficiency caused intracranial hemorrhage and hemorrhagic infarct in an infant. Early neuroimaging and hematological tests are crucial, even without external bleeding signs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycogen Storage Disease Type IXb in a 3-y-old Child.

Indian journal of pediatrics·2023
Same author

National Ethical Guidelines for biomedical and health research: Issues to ponder over.

Journal of postgraduate medicine·2022
Same author

Clinical and genetic spectrum of 104 Indian families with central nervous system white matter abnormalities.

Clinical genetics·2021
Same author

Physician Health in the Times of COVID-19.

The Journal of the Association of Physicians of India·2020
Same author

Ethics committees: Actions during pandemic and lockdown situations.

Journal of postgraduate medicine·2020
Same author

Predatory journals- Can we stem the rot?

Journal of postgraduate medicine·2019

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Medical Imaging

Background:

  • Factor VII deficiency is a rare inherited bleeding disorder.
  • Intracranial hemorrhage is a serious complication, particularly in neonates and infants.
  • Diagnosis often relies on clinical presentation and coagulation factor assays.

Observation:

  • A 1.5-month-old infant presented with seizures, lethargy, and feeding refusal.
  • Magnetic Resonance Imaging (MRI) revealed intracranial hemorrhage.
  • The MRI also showed an unusual hemorrhagic infarct.

Findings:

  • The infant was diagnosed with intracranial hemorrhage secondary to factor VII deficiency.
  • The co-occurrence of hemorrhagic infarct alongside intracranial hemorrhage is noteworthy.
  • This case highlights a potential link between factor VII deficiency and unusual cerebrovascular events.

Implications:

  • Emphasizes the need for prompt neuroimaging and hematological evaluation in infants with non-specific neurological symptoms.
  • Suggests that factor VII deficiency may predispose to both hemorrhage and infarction in the brain.
  • Underscores the importance of considering rare bleeding disorders in the differential diagnosis of pediatric intracranial hemorrhage.

Related Experiment Videos