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Related Experiment Videos

Histamine challenge in young children using computerized lung sounds analysis.

R Beck1, U Dickson, M D Montgomery

  • 1Department of Paediatrics, University of Calgary, Alberta, Canada.

Chest
|September 1, 1992
PubMed
Summary

This study developed a computerized lung sound analysis for histamine challenge tests (HCT) in children. The method objectively detects asthma in young children unable to perform spirometry, proving as sensitive as traditional methods.

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Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Diagnostic Technology

Background:

  • Histamine challenge testing (HCT) for asthma diagnosis is typically limited to older children capable of spirometry.
  • Diagnosing asthma in young children often relies on less objective methods like tracheal auscultation.
  • Computerized lung sound analysis (LSA) offers a potential objective method for wheeze detection.

Purpose of the Study:

  • To develop and validate a practical computerized system for objective histamine challenge testing (HCT) in children.
  • To enable HCT in young children who cannot perform spirometry.
  • To compare the sensitivity of computerized LSA during HCT with traditional methods.

Main Methods:

  • Lung sounds were recorded using a contact sensor during HCT.

Related Experiment Videos

  • Sounds were amplified, filtered, digitized, and analyzed using spectral LSA.
  • The computerized LSA wheeze pattern was compared to spirometry (PC20) and clinical symptoms in older children, and to symptoms and tracheal auscultation in younger children.

    • Main Results:

    • In older asthmatic children, LSA detected wheezing at half the histamine concentration required for a 20% fall in FEV1 in most cases.
    • In young asthmatic children, LSA identified wheezing at lower histamine concentrations than symptoms or tracheal auscultation.
    • Control subjects showed no wheezing patterns on LSA during HCT.

    Conclusions:

    • A sensitive computerized LSA method for HCT has been developed, applicable to young children.
    • This objective method expands the utility of HCT for asthma diagnosis in non-spirometric populations.
    • The computerized LSA approach demonstrates comparable or superior sensitivity to conventional diagnostic methods.