Related Experiment Video
Updated: Aug 24, 2026
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Another case of autosomal dominant exstrophy of the bladder
U G Froster1, W Heinritz, J Bennek
1Institute of Human Genetics, University of Leipzig, Leipzig, Germany. frou@medizin.uni-leipzig.de
Objective:
Exstrophy of the bladder is a rare malformation due to an anterior midline defect. Most cases of this condition with variable expression occur sporadically, but there are some cases indicative of a strong genetic component apart from environmental factors. This is a report about another rare mother-child pair with bladder exstrophy.
Methods:
We present the clinical data of a familial case of bladder exstrophy with an affected mother and her equally affected male fetus.
Results:
Prenatal diagnosis of bladder exstrophy in the fetus was assessed by ultrasound at the 19th gestational week and was confirmed after termination of pregnancy at the 21st gestational week.
Conclusion:
The present case may be additional evidence for an autosomal dominant inherited variant of this malformation complex with implication for counselling of affected patients.
Related Concept Videos
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
01:43Sex-linked Disorders
01:35Pedigree Analysis
01:23Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
01:20Disorders of the Urinary System
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
01:22Imaging Studies VI: Voiding Cystourethrography and Cystography