Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of the left-right axis.

N A Brown1, A McCarthy, J Seo

  • 1MRC Experimental Embryology and Teratology Unit, Saint George's Hospital Medical School, London, UK.

Ciba Foundation Symposium
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Optimization of a support vector regression model predicts maximal weight lifted during a manual material handling assessment within a military setting.

Applied ergonomics·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026
Same author

First Exclusive Reconstruction of the B^{*+}, B^{*0}, and B_{s}^{*0} Mesons and Precise Measurement of Their Masses.

Physical review letters·2026
Same author

Simultaneous Probe of the Charm and Bottom Quark Yukawa Couplings Using tt[over ¯]H Events.

Physical review letters·2026

Left-right asymmetry in embryonic development is determined by the first somite stage, not maternal signals or uterine orientation. This process involves two mirror-image axes and positional information for organ development.

Area of Science:

  • Developmental Biology
  • Embryology
  • Genetics

Background:

  • Left-right asymmetry is crucial for organogenesis.
  • The precise timing and mechanisms of left-right axis specification remain incompletely understood.
  • Conventional axes do not fully describe left-right patterning, which involves mirror-image proximodistal axes.

Purpose of the Study:

  • To determine the critical developmental stage for left-right axis specification.
  • To investigate potential maternal or uterine influences on embryonic left-right patterning.
  • To explore correlations between left-right abnormalities and genetic factors, such as in situs inversus models.

Main Methods:

  • Embryo culture from pre-neural plate stages to assess developmental plasticity.

Related Experiment Videos

  • Analysis of embryonic axis orientation relative to uterine environment.
  • Examination of situs inversus (iv/iv) mouse models to correlate genetic mutations with asymmetric development.

    • Main Results:

    • Left-right axis determination appears to be established by the first somite stage.
    • Early embryo culture leads to loss of normal left-right development, suggesting internal axis determination.
    • Uterine orientation and maternal signals are unlikely to dictate embryonic left-right axis.
    • Situs inversus mice exhibit correlations between left-right abnormalities, sex, and specific organ malformations (e.g., heart, spleen).

    Conclusions:

    • Left-right axis determination is an intrinsic embryonic process, likely set by the first somite stage.
    • External factors like uterine environment do not appear to control left-right patterning.
    • Further research into situs inversus models can elucidate genetic underpinnings of asymmetric organ development.