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Updated: Aug 9, 2026

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
Published on: December 21, 2016
Chromosomal aberrations in uranium and coal miners
G Wolf1, D Arndt, N Kotschy-Lang
1Berufsgenossenschaftliche Klinik für Berufskrankheiten Falkenstein, Lauterbacher Strasse 16, D-08223 Falkenstein, Germany. bwg2003@t-online.de
Purpose:
To compare chromosomal aberrations in peripheral lymphocytes of Wismut uranium miners (WUM) and Ruhr coal miners (RCM).
Materials And Methods:
Peripheral lymphocytes from 66 WUM and 29 RCM were cultured and analysed for structural chromosomal aberrations in Giemsa-stained M1 metaphases. Cytogenetic data from 23 male white-collar workers from public services were used as a historical control group.
Results:
The frequencies of chromosomal aberrations and sister chromatid exchanges in WUM and RCM were quite similar. Compared with public services workers, WUM and RCM had significantly higher frequencies of chromosomal aberrations.
Conclusions:
Chromosomal aberrations in WUM are not induced by radioactive particles inhaled during underground mining but as in RCM rather result from factors such as age, lifestyle, illnesses, medications and diagnostic irradiations.
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