Muscle blood flow in diabetes mellitus. Evidence of abnormality after exercise
R K Menon1, A A Grace, W Burgoyne
1Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, United Kingdom.
Objective:
To determine whether muscle blood flow before and after exercise is abnormal in patients with diabetes mellitus.
Research Design And Methods:
Muscle blood flow (MBF) was measured with the 133Xe clearance technique in 15 nondiabetic subjects, 10 patients with insulin-dependent diabetes mellitus (IDDM), and 11 patients with non-insulin-dependent diabetes (NIDDM) at rest and after exercise. None of the patients had neuropathy.
Results:
The median resting MBF was similar in all three groups. The median postexercise MBF was significantly greater in nondiabetic subjects (40.1 ml.min-1.100 g-1 of tissue) than in patients with IDDM (25.7 ml.min-1.100 g-1 of tissue; P less than 0.01) or NIDDM (14 ml.min-1.100 g-1 of tissue; P less than 0.01). The difference between IDDM and NIDDM was not significant.
Conclusions:
Diabetic patients have abnormalities of MBF in response to exercise. This abnormality occurs in the absence of clinical diabetic neuropathy.
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