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Published on: February 22, 2019
Variation in vaccine response in normal populations
Inna G Ovsyannikova1, Robert M Jacobson, Gregory A Poland
1Mayo Vaccine Research Group, 611C Guggenheim Building, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
Pharmacogenomics
|May 29, 2004
Summary
Human Leukocyte Antigen (HLA) gene variations significantly impact immune responses to vaccines like the measles vaccine. Understanding these genetic factors is crucial for developing more effective future vaccines.
Area of Science:
- Immunology
- Genetics
- Vaccinology
Background:
- Human Leukocyte Antigen (HLA) system gene polymorphisms are known to influence immune responses.
- Significant data highlight HLA genes' role in varying responses to the measles vaccine.
Purpose of the Study:
- To explore the genetic determinants of immune responses to viral vaccines, focusing on the measles vaccine.
- To elucidate the immunologic basis for variations in measles immunity.
Main Methods:
- Investigated associations between HLA class I, class II, TAP, and HLA-DM alleles and measles-specific antibody levels post-vaccination.
- Reviewed existing literature on HLA genotype associations with immune responses to other vaccines and infectious diseases.
Main Results:
- Identified specific HLA allele associations influencing measles vaccine response.
- Confirmed the role of HLA genes in modulating immune responses to various vaccines and pathogens, including hepatitis B and C, HPV, and influenza.
Conclusions:
- HLA genotype is a significant factor in individual immune responses to vaccines.
- Vaccine pharmacogenomics, particularly HLA associations, offers insights for designing novel peptide-based vaccines against measles and other infectious diseases.
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