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Basic techniques for aerosol delivery during mechanical ventilation.
1Division of Pulmonary, Critical Care, and Environmental Medicine, MA-421 Health Sciences Center; DC043.00, 1 Hospital Drive, University of Missouri-Columbia, Columbia, MO 65212, USA. dhandr@health.missouri.edu.
Respiratory Care
|May 29, 2004
Summary
Metered-dose inhalers and nebulizers are effective for delivering inhaled medications to mechanically ventilated patients. Proper administration techniques ensure aerosol delivery efficiency comparable to ambulatory patients, expanding therapeutic options.
Area of Science:
- Respiratory Medicine
- Pharmacology
- Medical Devices
Background:
- Metered-dose inhalers (MDIs) and nebulizers are used for aerosol delivery in mechanically ventilated patients.
- Ventilator circuits and artificial airways were considered significant obstacles to efficient aerosol delivery.
Purpose of the Study:
- To evaluate the efficiency of aerosol delivery to mechanically ventilated patients.
- To understand factors influencing inhaled drug delivery in this patient population.
Main Methods:
- Review of in vitro and in vivo investigations over the past decade.
- Analysis of factors affecting aerosol delivery in mechanically ventilated patients.
Main Results:
- Recent research clarifies factors influencing aerosol delivery in mechanically ventilated patients.
- Efficient aerosol delivery is achievable with appropriate administration techniques.
- Delivery efficiency can be comparable to that in ambulatory patients.
Conclusions:
- Careful administration techniques optimize aerosol delivery in mechanically ventilated patients.
- Efficient aerosol delivery supports wider clinical use of inhaled therapies in this group.