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Presence and extent of angiographic coronary narrowing in patients with left bundle branch block

Keith Nguyen1, Joaquin E Cigarroa, Richard A Lange

  • 1Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8837, USA.

The American Journal of Cardiology
|May 29, 2004
PubMed

Insights

Patients with coronary artery disease and left bundle branch block have higher mortality. However, severe coronary artery disease (CAD) involving the left main or three vessels is uncommon in these patients, regardless of left ventricular function.

Area of Science:

  • Cardiology
  • Medical Research

Background:

  • Coronary artery disease (CAD) patients with left bundle branch block (LBBB) face increased mortality.
  • The extent of CAD in patients with LBBB requires further investigation.

Purpose of the Study:

  • To determine the prevalence of significant coronary artery disease (left main or 3-vessel disease) in patients with LBBB undergoing coronary angiography.
  • To assess if left ventricular (LV) function influences the extent of CAD in this population.

Main Methods:

  • Retrospective analysis of 200 patients with LBBB referred for coronary angiography.
  • Evaluation of the extent of CAD, specifically left main or 3-vessel disease.
  • Stratification of patients based on left ventricular function (normal vs. depressed).

Main Results:

  • Only 13% of patients with LBBB had left main or 3-vessel CAD.
  • This prevalence was similar in patients with normal LV function (8%) and those with depressed LV function (16%).
  • Findings indicate limited severe CAD extent in LBBB patients.

Conclusions:

  • Significant coronary artery disease (left main or 3-vessel) is infrequent in patients with LBBB undergoing angiography.
  • Left ventricular function does not appear to significantly alter the extent of CAD in this patient group.
  • Further research may explore underlying mechanisms for increased mortality in CAD patients with LBBB despite less severe obstructive disease.

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