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Updated: Aug 24, 2026

Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation
Published on: January 7, 2019
Effect of perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to
Yuliy Y Chirkov1, Andrew S Holmes, Jason D Martelli
1Cardiology Unit, The Queen Elizabeth Hospital, Department of Medicine, The University of Adelaide, Woodville 5011, Adelaide, Southern Australia, Australia.
Abstract:
In 15 patients with chronic heart failure of ischemic origin who were not previously treated with angiotensin-converting enzyme inhibitors, platelets exhibited hyperaggregability and impaired responsiveness to the antiaggregatory and cyclic guanosine monophosphate-stimulatory effects of nitric oxide donor sodium nitroprusside compared with normal subjects; this was paralleled by increased blood levels of superoxide radicals. Treatment with perindopril for 4 days significantly improved platelet responses to sodium nitroprusside; there was also a trend toward a decrease in superoxide radical levels.
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