Data mining techniques to study the disulfide-bonding state in proteins: signal peptide is a strong descriptor
Dominique Tessier1, Benjamin Bardiaux, Colette Larré
1Unité de Recherche sur les Protéines Végétales et leurs Interactions, INRA Rue de la Géraudière, BP 71627, 44316 Nantes Cedex 3, France. tessier@nantes.inra.fr
Abstract:
In the eucaryotic cell, the formation of disulfide bonds takes place in general inside the endoplasmic reticulum which provides a unique folding environment. The DisulfideDB database gathers information about this biological process with structural, evolutionary and neighborhood information on cysteines in proteins. Mining this information with an association rule discovery program permits to extract some strong rules for the prediction of the disulfide-bonding state of cysteines.
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