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Related Experiment Videos

Association between body fat response to exercise training and multilocus ADR genotypes.

Dana A Phares1, Amy A Halverstadt, Alan R Shuldiner

  • 1Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA. db240@umail.umd.edu

Obesity Research
|May 29, 2004
PubMed
Summary
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Adrenergic receptor (ADR) gene variants and their interactions significantly influence how older adults lose body fat through exercise. These genetic factors explain a notable portion of the variability in exercise-induced fat loss.

Area of Science:

  • Genetics and Genomics
  • Exercise Physiology
  • Human Metabolism

Background:

  • Adrenergic receptors (ADR) play a role in regulating metabolism and fat breakdown.
  • Individual responses to exercise training, particularly fat loss, can vary significantly.
  • Genetic polymorphisms in ADR genes may contribute to this inter-individual variability.

Purpose of the Study:

  • To investigate the association between specific adrenergic receptor gene polymorphisms (alpha2b-ADR, beta3-ADR, beta2-ADR) and their interactions with exercise-induced changes in body fat.
  • To determine the contribution of these genetic factors to the variability in body fat response to a 24-week aerobic exercise intervention.

Main Methods:

  • An intervention study involving 70 healthy, sedentary older adults (50-75 years) with overweight/obesity.

Related Experiment Videos

  • Participants underwent 24 weeks of supervised aerobic exercise training following a 6-week dietary stabilization period.
  • Body fat composition (total body fat, trunk fat, fat mass) was assessed using DXA, and analyzed in relation to ADR gene polymorphisms (Glu12/Glu9 alpha2b-ADR, Trp64Arg beta3-ADR, Gln27Glu beta2-ADR) and their interactions.

    • Main Results:

    • Multivariate analysis revealed that main effects of all three ADR gene loci and their gene-gene interactions were significant predictors of percent total body fat and percent trunk fat response to exercise.
    • These combined genetic factors accounted for 17.5% of the variability in percent total body fat and 22% in percent trunk fat.
    • A trend was observed for the fat mass response model (p = 0.03), with genetic factors explaining 10% of its variability.

    Conclusions:

    • The body fat response to aerobic exercise training in older adults is significantly associated with the combined effects of specific ADR gene variants (alpha2b-ADR, beta3-ADR, beta2-ADR).
    • Gene-gene interactions among these ADR loci also play a crucial role in modulating the effectiveness of exercise for fat loss in this population.