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MR imaging of the stomach: potential use for mangafodipir trisodium--a study in swine

Chun S Zuo1, Peter R Seoane, Jiani Hu

  • 1Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. czuo@mclean.harvard.edu

Radiology
|May 29, 2004
PubMed
Abstract

Insights

Mangafodipir trisodium shows promise as a stomach MRI contrast agent, selectively enhancing the inner stomach lining in swine studies. This targeted enhancement differs from gadopentetate dimeglumine, suggesting potential for improved gastric imaging.

Area of Science:

  • Medical Imaging
  • Radiology
  • Gastroenterology

Background:

  • Magnetic resonance (MR) imaging is crucial for visualizing gastrointestinal structures.
  • Developing targeted contrast agents can improve diagnostic accuracy in stomach imaging.

Purpose of the Study:

  • To assess mangafodipir trisodium as a novel contrast agent for MR imaging of the stomach.
  • To compare its enhancement characteristics with a standard agent, gadopentetate dimeglumine.

Main Methods:

  • Intravenous administration of mangafodipir trisodium (5 micromol/kg) or gadopentetate dimeglumine (0.1 mmol/kg) in swine.
  • Acquisition of T1-weighted 3D MR images in vivo (1.5 T) and ex vivo (3.0 T).
  • Evaluation of contrast enhancement patterns and duodenal reflux in stomach specimens and in vivo.

Main Results:

  • Mangafodipir trisodium demonstrated prolonged, selective enhancement of the stomach's inner surface.
  • Gadopentetate dimeglumine resulted in more generalized stomach enhancement.
  • Ex vivo imaging confirmed mangafodipir trisodium's enhancement was confined to the inner stomach wall.

Conclusions:

  • Mangafodipir trisodium exhibits preferential enhancement of the gastric mucosa in swine MR imaging.
  • This selective enhancement suggests potential utility as a contrast agent for human stomach MR imaging.

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