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Updated: Jul 16, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Antigen bias in T cell cross-priming.

Monika C Wolkers1, Nathalie Brouwenstijn, Arnold H Bakker

  • 1Division of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

Science (New York, N.Y.)
|May 29, 2004
PubMed
Summary

Cross-priming, essential for CD8+ T cell activation against exogenous antigens, is inefficient for signal sequence-derived epitopes. This impairment may hinder immune detection of certain viral and tumor antigens, impacting vaccine design.

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